Age-related inflammation triggers skeletal stem/progenitor cell dysfunction
نویسندگان
چکیده
منابع مشابه
Age-related skeletal muscle dysfunction: causes and mechanisms.
Age-related muscle weakening may ultimately result in the transition from an independent to a dependent life-style. The decline in muscle strength is larger than expected from the loss of muscle mass. Single fibre studies and in vitro motility assays indicate that part of the muscle dysfunction is due to modifications of the myosin molecule. A lower rate of protein turnover may increase the cha...
متن کاملAge and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
1 School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast, United Kingdom, 2 Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, University of Ulster, C-TRIC Building, Altnagelvin Area Hospital, Londonderry, United Kingdom, 3 Care of Elderly Medicine, Belfast Health and Social Care Trust, Belfast, United Kingdom, 4 Regional G...
متن کاملImpaired progenitor cell activity in age-related endothelial dysfunction.
OBJECTIVES We investigated whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool. BACKGROUND Circulating progenitor cells with an endothelial phenotype contribute to the regeneration and repair of the vessel wall. An association between the loss of endothelial integrity and EPC modification ma...
متن کاملMethylated BSA Mimics Amyloid-Related Proteins and Triggers Inflammation
The mechanistic study of inflammatory or autoimmune diseases requires the generation of mouse models that reproduce the alterations in immune responses observed in patients. Methylated bovine serum albumin (mBSA) has been widely used to induce antigen-specific inflammation in targeted organs or in combination with single stranded DNA (ssDNA) to generate anti-nucleic acids antibodies in vivo. Ho...
متن کاملRestoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral "rejuvenating" factors that can restore regenerative function. Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Supplementation of systemic GD...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1810692116